The Duke Advanced Imaging Labs (DAI Labs) has a wide range of research projects in every aspect of digital chest imaging. These include the use of Bayesian statistical estimation to compensate for scattered radiation in chest radiographs, as well as to improve the appearance of solitary pulmonary nodules for lung cancer diagnosis. Tomosynthesis imaging allows a low-dose, cost-effective means of improving pulmonary nodule detection by rendering slice images in a longitudinal orientation. Dual energy imaging is a novel technique used to separate the chest radiograph into two component images containing only soft tissue and bone structures, respectively. Several computer-aided diagnosis projects are underway, including the use of artificial neural network predictive models to predict acute pulmonary embolism based on findings from the chest radiograph and ventilation/perfusion scans.
- Tomosynthesis for improved pulmonary nodule detection
- NIH/NCI R01 CA80490
Principal Investigator: James T. Dobbins, III, Ph.D.
Total Award: approx. $2,400,000 (1999-2006)
- Digital radiography research agreement with General Electric
- Principal Investigator: James T. Dobbins, III, Ph.D.
Total Award: approx. $255,000 (2000-06)
- Early Detection of Lung Cancer via Bi-Plane Correlation Chest Imaging
- NIH/NCI R21-CA-091806
Principal Investigator: Ehsan Samei, Ph.D.
Total Award: approx. $100,000 (2001-04)
- Bayesian Imaging for Improved Nodule Detection
- NIH/NCI 1R01 CA60849-01
Principal Investigator: Carey E. Floyd, Jr., Ph.D.
Total Award: approx. $1,130,000 (1994-99)
For more on Bayesian Imaging, please see this presentation.
- Dual Energy Screening for Nodular Disease
- NIH/NCI R01 CA55388
Principal Investigator: James T. Dobbins, III, Ph.D.
Total Award: approx. $1,200,000 (1992-99)
- Acute Pulmonary Embolism: Computer-Aided Diagnosis
- NIH/NHLBI R29 HL52826
Principal Investigator: Georgia Tourassi, Ph.D.
Total Award: approx. $513,000 (1994-99)
- Digital chest radiography with a digital beam attenuator
- NIH/NCI R23 CA43854
Principal Investigator: James T. Dobbins, III, Ph.D.
Total Award: approx. $108,000 (1986-89)
- Markov random field texture analysis and segmentation in digital chest radiography
- Investigators: Neal F. Vittitoe, Ph.D., Rene Vargas-Voracek, Ph.D.
- Computer-aided diagnosis of lung cancer in chest radiography
- Investigators: Neal F. Vittitoe, Ph.D.
- Computer-aided diagnosis of interstitial lung disease in chest radiography
- Investigators: Rene Vargas-Voracek, Ph.D., Carey E. Floyd, Jr., Ph.D.
- Automated extraction of image features for prediction of acute pulmonary embolism
- Investigators: Erik D. Frederick, Georgia Tourassi, Ph.D.
- Quantitative radiographic imaging using a photostimulable phosphor system.
- Investigators: Floyd, Chotas, Dobbins, Ravin
- Scatter fractions in AMBER images.
- Investigators: Chotas, Floyd, Dobbins, Ravin
- Single-exposure conventional and computed radiography imageacquisition.
- Investigators: Chotas, Dobbins, Ravin
(This paper won the 1992 Stauffer Award as best clinical research paper in the journal Investigative Radiology)
- Threshold perception performance with computed and screen-film radiography: implications for chest radiography.
- Investigators: Dobbins, Rice, Beam, Ravin
- Digital chest radiography using photostimulable storage phosphors: SNR as a function of kilovoltage with matched exposure risk.
- Investigators: Chotas, Floyd, Dobbins, Ravin
- Effects of undersampling on the proper interpretation of modulation transfer function, noise power spectra and noise equivalent quanta of digital imaging systems.
- Investigator: Dobbins
- DQE(f) of four generations of computed radiography acquisition devices.
- Investigators: Dobbins, Ergun, Rutz, Blume, Hinshaw, Clark
(This paper won the 1996 Sylvia Sorkin Greenfield Award for best scientific paper in the journal Medical Physics)
- Imaging characteristics of an amorphous silicon, flat-panel detector for digital chest radiography.
- Investigators: Floyd, Warp, Dobbins, Chotas, Baydush, Vargas-Voracek, Ravin
- Chest radiography: optimization of x-ray spectrum for cesium iodide-amorphous silicon flat-panel detector.
- Investigators: Dobbins, Samei, Chotas, Warp, Baydush, Floyd, Ravin
- Fundamental imaging characteristics of a slot-scan digital chest radiographic system.
- Investigators: Samei, Saunders, Lo, Dobbins, Jesneck, Floyd, Ravin
- Comparative scatter and dose performance of slot-scan and wide-beam digital chest radiographic systems.
- Investigators: Samei, Lo, Yoshizumi, Jesneck, Dobbins, Floyd, McAdams, Ravin
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